Speed - which would be faster

[statline]

I'm trying to create a fast database using MySQL, but I'm not sure how to give it the max power available.

If I have thousands of Select statements per minute should I:


Use 1 large table with all the data (40k - 60k entries)

or

should I use 1000 tables with less data in each table

Will one method be much faster than the other.

As well, should I use MyISAM or InnoDB tables ?

Thanks for the input

Sincerely
RG