Further Optimize my.cnf

[Chirag Patel]

lately for some reason I started noticing that my server has some issues and every now and then the sql would stop working and it would not even be able to restart.

Here is my my.cnf can you please think of some way I can further optimize it.
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[mysqld]
max_allowed_packet=100M
max_connections=1000
#safe-show-database
# Connection timeout
connect_timeout = 20

# Timeout for inactive connections
wait_timeout = 20

# Network buffer length (I think this is the linux default)
net_buffer_length = 16K
log-error = /etc/httpd/logs/mysqld.err
binlog_cache_size = 2M
table_cache = 6588
query_cache_size = 8M
join_buffer_size = 320M
thread_cache_size = 6
max_heap_table_size = 320M
#query_cache_size = 312M
key_buffer_size = 128M
[client]
socket=/var/lib/mysql/mysql.sock